Hyperbaric Oxygen Therapy and Cancer – A Review
“Hypoxia is a critical hallmark of solid tumors and involves enhanced cell survival, angiogenesis, glycolytic metabolism, and metastasis. Hyperbaric oxygen can be used to overcome hypoxia. HBO treatment enhances the amount of dissolved oxygen in the plasma, thereby increasing O2 tissue delivery independent of hemoglobin . As in normal tissue, the pO2 in cancer tissue increases significantly during HBO exposure . Thus, elevation of the tumor oxygen pressure has been shown to be preserved clinically for approximately 30 min after HBO exposure [12, 13]. HBO therapy is today accepted and routinely used for many disorders, related to both ischemia and/or hypoxia . HBO is considered safe and complications are rare using today’s standard treatment protocols.”
Oxygen, Key To Most Life, Decelerates Many Cancer Tumors When Combined With Radiation Therapy
“Over the past several years, the research of Dr. Mason, professor of radiology and the paper’s senior author, and his colleagues has been building on findings that show lack of oxygen actually stimulates the growth of new blood vessels in tumors and leads to metastasis and genetic instability in cancer.”
Hyperbaric Oxygen Creates chemosensitization by inhibiting HIF1α/HIF2α-Sox2
“The survival time of the two groups under the same TMZ treatment
was analyzed, and the results revealed that mice that were exposed to HBO had a longer survival time, with a median survival of approximately 37 days, than control mice, with a median survival time of only 30.5 days…”
Hyperbaric Oxygen Boosts Immune Responses Against Solid Tumors
“The results demonstrate that HBO promoted PD-1 Ab delivery and T cells infiltration into tumor parenchyma by depleting the extracellular matrix’s main components, such as collagen and fibronectin. Furthermore, HBO disrupts hypoxia-mediated immunosuppression and helps PD-1 Ab trigger robust cytotoxic T lymphocytes and long-lasting immunological memory to inhibit tumor relapses. Such enhanced immune responses are effective in solid tumors from rodents and the cancer cells from hepatocellular carcinoma patients. The results illustrate that HBO bolsters antitumor efficacy of PD-1 Ab, and the HBO-PD-1 Ab combination is a promising stroma-rich solid tumors’ treatment in the clinic.”
Mechanisms and Therapeutic Effectiveness of pulsed Electro Magnetic Field Therapy in Oncology
“The specific claim, supported by the described in vivo studies, is that all treated groups showed slower tumor growth rate if compared with untreated control group, confirming that PEMF therapy can modulate the physiology and electrochemistry of cancer cells and influence cell membrane systems and mitosis. In addition, PEMFs induce some changes in membrane transport capacity through impacting the osmotic potential, ionic valves and leading to reduction in cellular stress factors, increase in the rate of DNA transcription, and modulation of immune response. In conclusion, only two clinical studies have used PEMF therapy for cancer treatment. These studies show that PEMF therapy is safe and promising compared to other available cancer therapies.”
Dom D’Agostino, Ph.D.: ketosis, n=1, exogenous ketones, HBOT, seizures, and cancer
In this podcast the relationship between HBOT and cancer is discussed. They also go into detail discussing how Ketosis and HBOT work together to create results for people who are suffering from cancer.
Please note this is quite a science heavy based podcast but if you are wanting to understand the scientific evidence then we highly recommend you have a listen.